![]() If you’re eligible for a vaccine, we encourage you to talk with your healthcare provider.ĮVUSHELD TM still protects people from getting COVID-19, but it may offer less protection against three strains (BA.4.6, BF.7, and BA.2.75.2) of the Omicron variant. ![]() It is a medicine containing antibodies and is given before you are exposed to or test positive for COVID-19.ĮVUSHELD TM continues to be authorized for people who are moderately to severely immunocompromised and may not be able to mount an adequate response to the COVID-19 vaccine, and for people who could have a history of severe adverse reaction to the COVID-19 vaccine or its components. Food and Drug Administration (FDA) as pre-exposure prophylaxis to prevent COVID-19. ![]() Active treatment with high-dose corticosteroids (i.e., 20 or more mg of prednisone or equivalent per day when administered for 2 or more weeks), alkylating agents, antimetabolites, transplant-related immunosuppressive drugs, cancer chemotherapeutic agents classified as severely immunosuppressive, tumor necrosis factor (TNF) blockers, and other biologic agents that are immunosuppressive or immunomodulatoryĮVUSHELD TM is authorized by the U.S.Advanced or untreated HIV infection (people with HIV and CD4 cell counts less than 200/mm3, history of an AIDS-defining illness without immune reconstitution, or clinical manifestations of symptomatic HIV).Moderate or severe primary immunodeficiency (e.g., common variable immunodeficiency disease, severe combined immunodeficiency, DiGeorge syndrome, Wiskott-Aldrich syndrome).Receipt of chimeric antigen receptor (CAR)-T-cell therapy or hematopoietic stem cell transplant (within 2 years of transplantation or taking immunosuppressive therapy).Receipt of solid-organ transplant or an islet transplant and taking immunosuppressive therapy.Hematologic malignancies associated with poor responses to COVID-19 vaccines regardless of current treatment status (e.g., chronic lymphocytic leukemia, non-Hodgkin lymphoma, multiple myeloma, acute leukemia).Active treatment for solid tumor and hematologic malignancies.Examples of medical conditions or treatments that may result in moderate to severe immunocompromise include but are not limited to:
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